# pleural mesothelioma stages

Role of thoracoscopy, mediastinoscopy and laparoscopy in the diagnosis and staging of malignant pleural mesothelioma » Malignant pleural mesothelioma (MPM) is an aggressive malignancy with dismal prognosis. Unfortunately, chemotherapy only marginally extends patient survival and palliative care often remains the sole therapeutic option. Nonetheless, for a selected group… Ncbi.nlm.nih.gov

Malignant pleural mesothelioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up☆ » Incidence of malignant pleural mesothelioma (MPM) is generally higher in males than females and is attributed to historical differences in exposures with world-standardised incidence rates per 100 000 persons of 0.7 and 0.3 in the United States and 1.7 and 0.4 for Europe (for males and females, respectively). Incidence is highest in countries with greatest previous asbestos use such as the Netherlands, UK and Australia.1 Due to a lag time of ∼40 years between exposure and presentation, alongside relatively recent usage bans, incidence continues to rise in many countries. Annalsofoncology.org

Targeted next-generation sequencing of cancer genes in advanced stage malignant pleural mesothelioma: a retrospective study - PubMed » Next-generation sequencing was applied to a relatively large retrospective series of MPM using formalin-fixed, paraffin-embedded archival material. Our results indicate a complex mutational landscape with a higher number of genetic variations in the p53/DNA repair and phosphatidylinositol 3-kinase p … Pubmed.ncbi.nlm.nih.gov

Asbestos Exposure, Pleural Mesothelioma, and Serum Osteopontin Levels | NEJM » Original Article from The New England Journal of Medicine — Asbestos Exposure, Pleural Mesothelioma, and Serum Osteopontin Levels Nejm.org

Molecular and Histopathological Characterization of the Tumor Immune Microenvironment in Advanced Stage of Malignant Pleural Mesothelioma - PubMed » These data suggest that 60% of patients with MPM characterized by either PD-L1 expression or an inflamed status are attractive candidates for cancer immunotherapeutic options. Pubmed.ncbi.nlm.nih.gov

Surgery in Malignant Pleural Mesothelioma » Surgical intervention plays an important role in the diagnosis, staging, and treatment of malignant pleural mesothelioma (MPM) and can be applied with curative or palliative intent. The overall aim of surgery should be, as in any oncologic surgery, the macroscopic complete resection (MCR) of the tumor. Most importantly, the majority of patients with the diagnosis of MPM should be appropriately staged and initially evaluated in a multidisciplinary setting, including medical oncology, radiation oncology, and surgery after histologic diagnosis. Jto.org

The eighth TNM classification for malignant pleural mesothelioma » In 2016, the International Association for the Study of Lung Cancer (IASLC) published a number of revisions of the seventh edition of the tumor, node and metastasis (TNM) classification for malignant pleural mesothelioma (MPM). The purpose was to establish… Ncbi.nlm.nih.gov